2’-MOE

Oligonucleotides

2-Methoxyethyl RNA or 2’-MOE RNA is a nucleic acid analogue with promising features for Life Sciences applications. The only difference to normal RNA is the methoxy-ethyl residue attached to the 2’-O-position. This modification provides better target binding affinity, which makes it a very efficient molecule for antisense applications. We offer 2’-MOE with phosphodiester or phosphorothioate linkages. Phosphorothioate bonds are phosphodiester analogues in which the non-bridging oxygen has been replaced by sulphur, increasing resistance against nuclease digestion.

Higher binding affinity towards its complementary target

Offers an enhanced biological half-life

Very good for antisense oligonucleotide design

Ordering Information

Product - Synthesis code

Product #

Synthesis scale & other scales on request

2’-MOE RNA –

MOE01-200
200 nmol

moA, moG, moC, moT

MOE01-M02
2 μmol
MOE01-M05
5 μmol
MOE01-M10
10 μmol

2’-MOE RNA + Phosphorothioate linkage –

MOE02-200

200 nmol

moA*, moG*, moC*, moT*

MOE01-M01
1 μmol
MOE02-M02
2 μmol
MOE02-M05
5 μmol
MOE02-M10
10 μmol

How to order

Simply fill out our online form