Reliable and robust DNA oligonucleotides with phosphodiester or phosphorothioate linkages. Phosphorothioate bonds are phosphodiester analogues in which the non-bridging oxygen has been replaced by sulphur, increasing the resistance against nuclease digestion. Further modifications at the 3’- and 5’- ends are available including 6-Carboxyfluorescein, Amine, Biotin, Phosphate, Thiol C6 S-S, Cholesterol, and Vitamine-E (Alpha-Tocopherol).
dA, dG, dC, dT
DNA + Phosphorothioate linkage –
dA*, dG*, dC*, dT*