RNA, DNA and custom modified oligonucleotides.
Custom RNA, DNA and modified oligonucleotides, with an extensive range of modifications and conjugations.
A full catalogue, built to your specification.
Whatever the application, we synthesise to your exact specification, and the same team that makes your material can help characterise it and, through Syngenis Clinical, take it toward the clinic.
RNA.
Synthetic RNA sequences as single or double stranded oligos, with a choice of phosphodiester or phosphorothioate linkage and additional tags at either end (FAM, Biotin or phosphate). Available as phosphodiester (rA, rC, rG, rU) and phosphorothioate (rA*, rC*, rG*, rU*).
DNA.
Custom DNA oligonucleotides synthesised to your specification with phosphodiester or phosphorothioate linkage and the addition of specific tags including FAM, Biotin or phosphate. Available as phosphodiester (dA, dC, dG, dT) and phosphorothioate (dA*, dC*, dG*, dT*).
Custom modified RNA.
Modified RNA oligonucleotides with 2' O methyl (2' OMe), 2' O methoxyethyl (2' MOE), 2' fluoro (2' F) or locked nucleic acid (LNA) chemistry, with phosphodiester or phosphorothioate linkage. Includes 2' OMe (mA, mC, mG, mU), 2' MOE (moA, moC, moG, moT), 2' fluoro (fA, fC, fG, fU) and LNA (lA, lC, lG, lT), each available with a phosphorothioate backbone.
Available modifications and conjugations.
- Linkers and functional groups: Biotin, Biotin TEG, Amino (C3, C6, C12), Thiol (C3, C6), Alkyne, Azide, DBCO, Cholesterol TEG.
- Spacers: C3, C6, C12, C18, Spacer 9 (TEG), dSpacer (abasic), PC spacer.
- Quenchers: BHQ-1, BHQ-2, BHQ-3, BBQ-650, Dabcyl, Eclipse, MGB.
- Fluorophores: FAM, HEX, TAMRA, Cy3, Cy3.5, Cy5, Cy5.5, ATTO550, AF488, Methylene Blue.
- Conjugations: DOTA, NOTA, NODAGA, GalNAc, PEG, Cholesterol, alpha tocopherol, Digoxigenin.
- Custom modifications: custom end, internal and dual labelled modifications available on request.
Applications we support.
Our products support therapeutic development (antisense and RNA silencing candidates such as those now approved for rare neurological, cardiometabolic and metabolic disease), diagnostics (probes, primers and aptamers for assays and point of care tests), and research across universities and institutes.
Ready to work with an integrated life sciences company?
Talk to our team about your program, from candidate design to trial ready material.