2’-Fluoro-RNA

Oligonucleotides

2’-Fluoro-RNA (2’-FRNA) contains a highly electronegative fluorine molecule at the 2’-ribose position resulting in a ring with C3’-endo conformation. Therefore, the oligonucleotide adopts stable A-form helix on hybridization to a target. This modification is particularly useful as antisense molecules, aptamers, siRNAs and miRNAs molecules. We offer 2’-Fluoro-RNA with phosphodiester or phosphorothioate linkages. Phosphorothioate bonds are phosphodiester analogues in which the non-bridging oxygen has been replaced by sulphur, increasing resistance against nuclease digestion.

Ordering Information

Product - Synthesis code

Product #

Synthesis scale & other scales on request

2′-F RNA –

FRNA01-200
200 nmol

fA, fG, fC, fU

FRNA01-M02

2 μmol

FRNA01-M05

5 μmol

FRNA01-M10

10 μmol

2′-F RNA + Phosphorothioate linkage –

FRNA02-200

200 nmol

fA*, fG*, fC*, fU*

FRNA01-M01

1 μmol

FRNA02-M02

2 μmol

FRNA02-M05

5 μmol

FRNA02-M10

10 μmol

How to order

Simply fill out our online form