2’-O-Methyl-RNA or 2′-OMe modified oligos are more chemically stable compared to regular RNA, which makes them attractive chemistry for antisense, siRNA or miRNA therapeutic applications. They have increased thermal stability and resistance to nucleases. We offer 2’-OMe with phosphodiester or phosphorothioate linkages. Phosphorothioate bonds are phosphodiester analogues in which the non-bridging oxygen has been replaced by sulphur, increasing resistance against nuclease digestion.