Reliable and robust RNA oligonucleotides with phosphodiester or phosphorothioate linkage. Phosphorothioate bonds are phosphodiester analogues in which non-bridging oxygen has been replaced by sulphur, increasing resistance against nuclease digestion. Further modifications at the 3’ and 5’ ends are available including 6- Carboxyfluorescein, Amine, Biotin, Phosphate, Cholesterol, Thiol C6 S-S and Vitamine-E (Alpha- Tocopherol).
rA, rC, rG, rU
RNA + Phosphorothioate linkage –
rA*, rC*, rG*, rU*